Assay Detail

CHEMBL896016

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Functional

Growth inhibition of human SHP77 cells after 3 hrs by MTT assay

ChEMBL ↗

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Target

SHP77 (CHEMBL612569) ↗

Open DB target context

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Primary target SHP77

CHEMBL612569

Anchored from Assay target.

Protein identity SHP77

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SHP77
Confidence	1 — Organism
Curated By	Autocuration

Target

SHP77 (CHEMBL612569) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.

Kalet BT, McBryde MB, Espinosa JM, Koch TH.
J Med Chem (2007) 50 : 4493 -4500
PubMed 17696516 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL217089	DOXAZOLIDINE	—	1	8.70
CHEMBL53463	DOXORUBICIN	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL217089	DOXAZOLIDINE	IC50	=	1.995	nM	8.70
CHEMBL53463	DOXORUBICIN	IC50	>	1000.0	nM	-