Assay Detail

CHEMBL896020

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Functional

Growth inhibition of human MiaPaCa2 cells after 3 hrs by MTT assay

ChEMBL ↗

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Target

MIA PaCa-2 (CHEMBL614725) ↗

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MIA PaCa-2 (CHEMBL614725) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MIA PaCa-2

CHEMBL614725

Anchored from Assay target.

Protein identity MIA PaCa-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MIA PaCa-2
Confidence	1 — Organism
Curated By	Autocuration

Target

MIA PaCa-2 (CHEMBL614725) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.

Kalet BT, McBryde MB, Espinosa JM, Koch TH.
J Med Chem (2007) 50 : 4493 -4500
PubMed 17696516 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.50	8.50

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL217089	DOXAZOLIDINE	—	1	8.50
CHEMBL53463	DOXORUBICIN	4.0	1	6.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL217089	DOXAZOLIDINE	IC50	=	3.162	nM	8.50
CHEMBL53463	DOXORUBICIN	IC50	=	316.23	nM	6.50