Assay Detail

CHEMBL896025

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Functional

Growth inhibition of human SF268 cells after 48 hrs by MTT assay

ChEMBL ↗

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Target

SF-268 (CHEMBL613977) ↗

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Primary target SF-268

CHEMBL613977

Anchored from Assay target.

Protein identity SF-268

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SF-268
Confidence	1 — Organism
Curated By	Intermediate

Target

SF-268 (CHEMBL613977) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.

Kalet BT, McBryde MB, Espinosa JM, Koch TH.
J Med Chem (2007) 50 : 4493 -4500
PubMed 17696516 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.81	8.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL217089	DOXAZOLIDINE	—	1	8.58
CHEMBL53463	DOXORUBICIN	4.0	1	7.04

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL217089	DOXAZOLIDINE	IC50	=	2.63	nM	8.58
CHEMBL53463	DOXORUBICIN	IC50	=	91.2	nM	7.04