Assay Detail
Binding
CHEMBL896200
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Inhibition of PKA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.50 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245212 | — | — | 1 | 4.99 |
| CHEMBL436817 | — | — | 1 | 4.40 |
| CHEMBL230654 | — | — | 1 | 4.12 |
| CHEMBL230761 | — | — | 1 | - |
| CHEMBL425834 | — | — | 1 | - |
| CHEMBL230232 | — | — | 1 | - |
| CHEMBL395573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245212 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL436817 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL230654 | — | IC50 | = | 76100.0 | nM | 4.12 |
| CHEMBL230761 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL425834 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL230232 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL395573 | — | IC50 | > | 40000.0 | nM | - |