Assay Detail
Binding
CHEMBL896246
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Inhibition of protein farnesyltransferase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.97 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428712 | — | — | 1 | 8.77 |
| CHEMBL395222 | — | — | 1 | 8.59 |
| CHEMBL365742 | — | — | 1 | 8.52 |
| CHEMBL232104 | — | — | 1 | 8.49 |
| CHEMBL191843 | — | — | 1 | 8.47 |
| CHEMBL192244 | — | — | 1 | 8.42 |
| CHEMBL234757 | — | — | 1 | 8.32 |
| CHEMBL192898 | — | — | 1 | 8.30 |
| CHEMBL232523 | — | — | 1 | 8.26 |
| CHEMBL234151 | — | — | 1 | 8.19 |
| CHEMBL231662 | — | — | 1 | 8.15 |
| CHEMBL233742 | — | — | 1 | 8.12 |
| CHEMBL394086 | — | — | 1 | 8.11 |
| CHEMBL365549 | — | — | 1 | 8.00 |
| CHEMBL394407 | — | — | 1 | 7.80 |
| CHEMBL392237 | — | — | 1 | 7.60 |
| CHEMBL234161 | — | — | 1 | 6.98 |
| CHEMBL371408 | — | — | 1 | 6.36 |
| CHEMBL193161 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428712 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL395222 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL365742 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL232104 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL191843 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL192244 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL234757 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL192898 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL232523 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL234151 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL231662 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL233742 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL394086 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL365549 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL394407 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL392237 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL234161 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL371408 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL193161 | — | IC50 | = | 1000.0 | nM | 6.00 |