Assay Detail
Binding
CHEMBL896291
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Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR/5HT3A in tsA201 cells
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | tsA201 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.74 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | — | 2 | 8.80 |
| CHEMBL229998 | — | — | 2 | 7.75 |
| CHEMBL395727 | — | — | 2 | 6.48 |
| CHEMBL231056 | — | — | 2 | 6.08 |
| CHEMBL415568 | — | — | 2 | 6.01 |
| CHEMBL382243 | — | — | 2 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 1.622 | nM | 8.79 |
| CHEMBL229998 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL229998 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL395727 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL395727 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL231056 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL231056 | — | Ki | = | 851.14 | nM | 6.07 |
| CHEMBL415568 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL415568 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL382243 | — | Ki | = | 4420.0 | nM | 5.36 |
| CHEMBL382243 | — | Ki | = | 4466.84 | nM | 5.35 |