Assay Detail
Binding
CHEMBL896294
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Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR R79A mutant/5HT3A receptor R79A mutant in tsA201 cells
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | tsA201 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.50 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | — | 2 | 8.46 |
| CHEMBL229998 | — | — | 2 | 7.50 |
| CHEMBL395727 | — | — | 2 | 6.18 |
| CHEMBL231056 | — | — | 2 | 5.89 |
| CHEMBL415568 | — | — | 2 | 5.86 |
| CHEMBL382243 | — | — | 2 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL229998 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL229998 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL395727 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL395727 | — | Ki | = | 660.69 | nM | 6.18 |
| CHEMBL231056 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL231056 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL415568 | — | Ki | = | 1380.38 | nM | 5.86 |
| CHEMBL415568 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL382243 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL382243 | — | Ki | = | 7585.78 | nM | 5.12 |