Assay Detail
Binding
CHEMBL896298
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Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR S148A mutant /5HT3A receptor in tsA201 cells
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | tsA201 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.71 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | — | 2 | 8.60 |
| CHEMBL229998 | — | — | 2 | 6.80 |
| CHEMBL231056 | — | — | 2 | 6.40 |
| CHEMBL382243 | — | — | 2 | 6.37 |
| CHEMBL395727 | — | — | 2 | 6.10 |
| CHEMBL415568 | — | — | 2 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL229998 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL229998 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL231056 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL231056 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL382243 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL382243 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL395727 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL395727 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL415568 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL415568 | — | Ki | = | 1047.13 | nM | 5.98 |