Assay Detail
Binding
CHEMBL896302
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Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR Y168A mutant/5HT3A receptor in tsA201 cells
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | tsA201 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.64 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | — | 2 | 8.72 |
| CHEMBL229998 | — | — | 2 | 7.47 |
| CHEMBL395727 | — | — | 2 | 6.51 |
| CHEMBL231056 | — | — | 2 | 5.96 |
| CHEMBL415568 | — | — | 2 | 5.89 |
| CHEMBL382243 | — | — | 2 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL229998 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL229998 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL395727 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL395727 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL231056 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL231056 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL415568 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL415568 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL382243 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL382243 | — | Ki | = | 5128.61 | nM | 5.29 |