Assay Detail
Functional
CHEMBL896364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARdelta expressed in HepG2 cells after 16 hrs by luciferase reporter gene assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.28 | 7.89 |
| IC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234659 | — | — | 1 | 7.89 |
| CHEMBL232400 | — | — | 1 | 7.16 |
| CHEMBL234665 | — | — | 1 | 6.64 |
| CHEMBL234660 | — | — | 1 | 6.60 |
| CHEMBL232397 | — | — | 1 | 6.60 |
| CHEMBL392949 | — | — | 1 | 6.57 |
| CHEMBL232395 | — | — | 1 | 6.53 |
| CHEMBL391478 | — | — | 1 | 6.43 |
| CHEMBL233177 | — | — | 1 | 6.28 |
| CHEMBL232398 | — | — | 1 | 6.23 |
| CHEMBL234661 | — | — | 1 | 6.03 |
| CHEMBL392950 | — | — | 1 | 5.76 |
| CHEMBL234662 | — | — | 1 | 5.71 |
| CHEMBL234663 | — | — | 1 | 5.66 |
| CHEMBL267147 | — | — | 1 | 5.58 |
| CHEMBL232399 | — | — | 1 | 4.87 |
| CHEMBL232396 | — | — | 1 | - |
| CHEMBL391479 | — | — | 1 | - |
| CHEMBL234666 | — | — | 1 | - |
| CHEMBL392951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234659 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL232400 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL234665 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL234660 | — | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL232397 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL392949 | — | EC50 | = | 267.0 | nM | 6.57 |
| CHEMBL232395 | — | EC50 | = | 295.0 | nM | 6.53 |
| CHEMBL391478 | — | EC50 | = | 374.0 | nM | 6.43 |
| CHEMBL233177 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL232398 | — | EC50 | = | 585.0 | nM | 6.23 |
| CHEMBL234661 | — | EC50 | = | 933.0 | nM | 6.03 |
| CHEMBL392950 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL234662 | — | EC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL234663 | — | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL267147 | — | EC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL232399 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL232396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL391479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL234666 | — | EC50 | - | — | - | |
| CHEMBL392951 | — | EC50 | - | — | - |