Assay Detail
Binding
CHEMBL896429
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Inhibition of DPP4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.21 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233564 | — | — | 1 | 9.17 |
| CHEMBL233563 | — | — | 1 | 8.28 |
| CHEMBL392924 | — | — | 1 | 8.18 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.75 |
| CHEMBL233360 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233564 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL233563 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL392924 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL233360 | — | IC50 | = | 21.0 | nM | 7.68 |