Assay Detail
Binding
CHEMBL896466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.48 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 8.59 |
| CHEMBL231690 | — | — | 1 | 8.55 |
| CHEMBL233976 | — | — | 1 | 8.51 |
| CHEMBL234589 | — | — | 1 | 8.44 |
| CHEMBL234801 | — | — | 1 | 8.17 |
| CHEMBL233978 | — | — | 1 | 8.11 |
| CHEMBL391457 | — | — | 1 | 7.96 |
| CHEMBL231689 | — | — | 1 | 7.89 |
| CHEMBL265868 | — | — | 1 | 7.85 |
| CHEMBL234588 | — | — | 1 | 7.82 |
| CHEMBL391085 | — | — | 1 | 7.64 |
| CHEMBL234799 | — | — | 1 | 7.62 |
| CHEMBL234168 | — | — | 1 | 7.60 |
| CHEMBL393767 | — | — | 1 | 7.51 |
| CHEMBL234382 | — | — | 1 | 7.43 |
| CHEMBL234170 | — | — | 1 | 7.43 |
| CHEMBL234587 | — | — | 1 | 7.37 |
| CHEMBL234169 | — | — | 1 | 7.24 |
| CHEMBL234800 | — | — | 1 | 7.09 |
| CHEMBL391068 | — | — | 1 | 7.09 |
| CHEMBL393373 | — | — | 1 | 7.04 |
| CHEMBL393765 | — | — | 1 | 7.01 |
| CHEMBL391084 | — | — | 1 | 6.62 |
| CHEMBL234383 | — | — | 1 | 6.61 |
| CHEMBL234381 | — | — | 1 | 6.43 |
| CHEMBL393766 | — | — | 1 | 6.18 |
| CHEMBL231688 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL231690 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL233976 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL234589 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL234801 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL233978 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL391457 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL231689 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL265868 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL234588 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL391085 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL234799 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL234168 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL393767 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL234382 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL234170 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL234587 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL234169 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL234800 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL391068 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL393373 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL393765 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL391084 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL234383 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL234381 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL393766 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL231688 | — | IC50 | = | 734.0 | nM | 6.13 |