Assay Detail
Binding
CHEMBL896467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenoxy)-2-methylbutanoic acid from human PPARalpha after 30 mins by SPA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.99 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231690 | — | — | 1 | 6.76 |
| CHEMBL231689 | — | — | 1 | 6.75 |
| CHEMBL234589 | — | — | 1 | 6.64 |
| CHEMBL391457 | — | — | 1 | 6.58 |
| CHEMBL391085 | — | — | 1 | 6.51 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 6.33 |
| CHEMBL233976 | — | — | 1 | 6.32 |
| CHEMBL234801 | — | — | 1 | 6.26 |
| CHEMBL393373 | — | — | 1 | 6.25 |
| CHEMBL265868 | — | — | 1 | 6.17 |
| CHEMBL391084 | — | — | 1 | 6.17 |
| CHEMBL393767 | — | — | 1 | 6.08 |
| CHEMBL234588 | — | — | 1 | 6.02 |
| CHEMBL234169 | — | — | 1 | 5.98 |
| CHEMBL393765 | — | — | 1 | 5.87 |
| CHEMBL234168 | — | — | 1 | 5.85 |
| CHEMBL234382 | — | — | 1 | 5.83 |
| CHEMBL234800 | — | — | 1 | 5.62 |
| CHEMBL391068 | — | — | 1 | 5.62 |
| CHEMBL234799 | — | — | 1 | 5.60 |
| CHEMBL234381 | — | — | 1 | 5.42 |
| CHEMBL233978 | — | — | 1 | 5.42 |
| CHEMBL234587 | — | — | 1 | 5.33 |
| CHEMBL234170 | — | — | 1 | 5.24 |
| CHEMBL234383 | — | — | 1 | 5.11 |
| CHEMBL231688 | — | — | 1 | - |
| CHEMBL393766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231690 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL231689 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL234589 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL391457 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL391085 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL38943 | GW501516 | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL233976 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL234801 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL393373 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL265868 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL391084 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL393767 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL234588 | — | IC50 | = | 963.0 | nM | 6.02 |
| CHEMBL234169 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL393765 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL234168 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL234382 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL234800 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL391068 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL234799 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL234381 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL233978 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL234587 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL234170 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL234383 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL231688 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL393766 | — | IC50 | > | 10000.0 | nM | - |