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Assay Detail

CHEMBL896486

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Binding
Inhibition of human cytomegalovirus DNA polymerase
ChEMBL ↗
44
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cytomegalovirus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.
Larsen SD, Zhang Z, DiPaolo BA, Manninen PR, Rohrer DC, Hageman MJ, Hopkins TA, Knechtel ML, Oien NL, Rush BD, Schwende FJ, Stefanski KJ, Wieber JL, Wilkinson KF, Zamora KM, Wathen MW, Brideau RJ.
Bioorg Med Chem Lett (2007) 17 : 3840 -3844
PubMed 17513108 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.74 8.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL232755 — — 1 8.01
CHEMBL232953 — — 1 7.82
CHEMBL233612 — — 1 7.77
CHEMBL399594 — — 2 7.77
CHEMBL394023 — — 1 7.72
CHEMBL233614 — — 1 7.70
CHEMBL231913 — — 1 7.70
CHEMBL232115 — — 1 7.58
CHEMBL232952 — — 1 7.52
CHEMBL231914 — — 1 7.50
CHEMBL391438 — — 1 7.43
CHEMBL400604 — — 1 7.39
CHEMBL233179 — — 1 7.22
CHEMBL232954 — — 1 7.17
CHEMBL428190 — — 1 7.14
CHEMBL232562 — — 1 7.10
CHEMBL232753 — — 1 7.03
CHEMBL393378 — — 1 7.00
CHEMBL232564 — — 1 7.00
CHEMBL231701 — — 1 6.85
CHEMBL233613 — — 1 6.80
CHEMBL269005 — — 1 6.75
CHEMBL400836 — — 1 6.70
CHEMBL233804 — — 1 6.68
CHEMBL400605 — — 1 6.66
CHEMBL394024 — — 1 6.60
CHEMBL232361 — — 1 6.60
CHEMBL399798 — — 1 6.51
CHEMBL29711 APHIDICOLIN — 1 6.40
CHEMBL231706 — — 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL232755 — IC50 = 9.7 nM 8.01
CHEMBL232953 — IC50 = 15.0 nM 7.82
CHEMBL399594 — IC50 = 17.0 nM 7.77
CHEMBL233612 — IC50 = 17.0 nM 7.77
CHEMBL399594 — IC50 = 17.0 nM 7.77
CHEMBL394023 — IC50 = 19.0 nM 7.72
CHEMBL231913 — IC50 = 20.0 nM 7.70
CHEMBL233614 — IC50 = 20.0 nM 7.70
CHEMBL232115 — IC50 = 26.0 nM 7.58
CHEMBL232952 — IC50 = 30.0 nM 7.52
CHEMBL231914 — IC50 = 32.0 nM 7.50
CHEMBL391438 — IC50 = 37.0 nM 7.43
CHEMBL400604 — IC50 = 41.0 nM 7.39
CHEMBL233179 — IC50 = 60.0 nM 7.22
CHEMBL232954 — IC50 = 67.0 nM 7.17
CHEMBL428190 — IC50 = 72.0 nM 7.14
CHEMBL232562 — IC50 = 80.0 nM 7.10
CHEMBL232753 — IC50 = 93.0 nM 7.03
CHEMBL232564 — IC50 = 100.0 nM 7.00
CHEMBL393378 — IC50 = 100.0 nM 7.00
CHEMBL231701 — IC50 = 140.0 nM 6.85
CHEMBL233613 — IC50 = 160.0 nM 6.80
CHEMBL269005 — IC50 = 180.0 nM 6.75
CHEMBL400836 — IC50 = 200.0 nM 6.70
CHEMBL233804 — IC50 = 210.0 nM 6.68
CHEMBL400605 — IC50 = 220.0 nM 6.66
CHEMBL232361 — IC50 = 250.0 nM 6.60
CHEMBL394024 — IC50 = 250.0 nM 6.60
CHEMBL399798 — IC50 = 310.0 nM 6.51
CHEMBL29711 APHIDICOLIN IC50 = 400.0 nM 6.40
CHEMBL231706 — IC50 = 420.0 nM 6.38
CHEMBL232563 — IC50 = 510.0 nM 6.29
CHEMBL233424 — IC50 = 580.0 nM 6.24
CHEMBL231700 — IC50 = 590.0 nM 6.23
CHEMBL233178 — IC50 = 1100.0 nM 5.96
CHEMBL233770 — IC50 = 1200.0 nM 5.92
CHEMBL232754 — IC50 = 1800.0 nM 5.75
CHEMBL233557 — IC50 = 2300.0 nM 5.64
CHEMBL666 FOSCARNET IC50 = 2500.0 nM 5.60
CHEMBL392777 — IC50 = 3000.0 nM 5.52
CHEMBL233425 — IC50 = 10600.0 nM 4.97
CHEMBL233556 — IC50 = 12400.0 nM 4.91
CHEMBL193952 ZIDOVUDINE TRIPHOSPHATE IC50 = 22100.0 nM 4.66
CHEMBL233558 — IC50 > 20000.0 nM -