Assay Detail
Binding
CHEMBL896490
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Inhibition of VZV DNA polymerase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.93 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232115 | — | — | 1 | 8.24 |
| CHEMBL233179 | — | — | 1 | 7.68 |
| CHEMBL232954 | — | — | 1 | 7.27 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.22 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.24 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232115 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL233179 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL232954 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL666 | FOSCARNET | IC50 | - | — | - |