Assay Detail
Functional
CHEMBL896511
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Cytotoxic activity against HeLa cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.61 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392369 | — | — | 1 | 6.68 |
| CHEMBL400633 | — | — | 1 | 6.50 |
| CHEMBL232133 | — | — | 1 | 6.28 |
| CHEMBL232728 | — | — | 1 | 5.76 |
| CHEMBL232121 | — | — | 1 | 5.75 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.48 |
| CHEMBL396414 | — | — | 1 | 4.92 |
| CHEMBL398146 | — | — | 1 | 4.78 |
| CHEMBL231939 | — | — | 1 | 4.30 |
| CHEMBL863 | CYSTEINE | 4.0 | 1 | - |
| CHEMBL433998 | — | — | 1 | - |
| CHEMBL392255 | — | — | 1 | - |
| CHEMBL397565 | — | — | 1 | - |
| CHEMBL396416 | CARBOCYSTEINE | 3.0 | 1 | - |
| CHEMBL302212 | — | — | 1 | - |
| CHEMBL63130 | BENZYLCYSTEINE | — | 1 | - |
| CHEMBL231992 | — | — | 1 | - |
| CHEMBL394875 | — | — | 1 | - |
| CHEMBL232727 | — | — | 1 | - |
| CHEMBL415259 | — | — | 1 | - |
| CHEMBL233547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392369 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL400633 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL232133 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL232728 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL232121 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL396414 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL398146 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL231939 | — | IC50 | = | 49700.0 | nM | 4.30 |
| CHEMBL863 | CYSTEINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL433998 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL392255 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL397565 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL396416 | CARBOCYSTEINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL302212 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL63130 | BENZYLCYSTEINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL231992 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL394875 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL232727 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL415259 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL233547 | — | IC50 | > | 50000.0 | nM | - |