Assay Detail
Binding
CHEMBL896601
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Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.32 | 10.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39174 | — | — | 1 | 10.02 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 9.59 |
| CHEMBL236289 | — | — | 1 | 9.57 |
| CHEMBL236291 | — | — | 1 | 9.22 |
| CHEMBL391512 | — | — | 1 | 9.15 |
| CHEMBL236290 | — | — | 1 | 9.11 |
| CHEMBL41036 | — | — | 1 | 8.96 |
| CHEMBL391367 | — | — | 1 | 8.89 |
| CHEMBL236080 | — | — | 1 | 8.57 |
| CHEMBL440975 | — | — | 1 | 8.23 |
| CHEMBL236499 | — | — | 1 | 7.92 |
| CHEMBL236498 | — | — | 1 | 7.58 |
| CHEMBL391513 | — | — | 1 | 6.54 |
| CHEMBL393201 | — | — | 1 | 5.85 |
| CHEMBL236500 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39174 | — | IC50 | = | 0.095 | nM | 10.02 |
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL236289 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL236291 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL391512 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL236290 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL41036 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL391367 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL236080 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL440975 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL236499 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL236498 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL391513 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL393201 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL236500 | — | IC50 | = | 2600.0 | nM | 5.58 |