Assay Detail
Binding
CHEMBL896603
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Activity against TRAF-alpha-1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay
25
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.86 | 9.42 |
| Activity | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39174 | — | — | 1 | 9.42 |
| CHEMBL236289 | — | — | 2 | 8.85 |
| CHEMBL236291 | — | — | 2 | 8.82 |
| CHEMBL41036 | — | — | 1 | 8.77 |
| CHEMBL391512 | — | — | 2 | 8.64 |
| CHEMBL391367 | — | — | 2 | 8.14 |
| CHEMBL440975 | — | — | 2 | 7.82 |
| CHEMBL236499 | — | — | 2 | 7.77 |
| CHEMBL393201 | — | — | 2 | 7.19 |
| CHEMBL236498 | — | — | 2 | 7.18 |
| CHEMBL236080 | — | — | 2 | 6.99 |
| CHEMBL236500 | — | — | 2 | 6.77 |
| CHEMBL391513 | — | — | 2 | 5.82 |
| CHEMBL236290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39174 | — | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL236289 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL236291 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL41036 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL391512 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL391367 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL440975 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL236499 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL393201 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL236498 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL236080 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL236500 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL391513 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL391513 | — | Activity | = | 72.0 | % | - |
| CHEMBL236498 | — | Activity | = | 74.0 | % | - |
| CHEMBL236291 | — | Activity | = | 65.0 | % | - |
| CHEMBL236499 | — | Activity | = | 78.0 | % | - |
| CHEMBL391512 | — | Activity | = | 88.0 | % | - |
| CHEMBL393201 | — | Activity | = | 21.0 | % | - |
| CHEMBL236289 | — | Activity | = | 78.0 | % | - |
| CHEMBL236500 | — | Activity | = | 13.0 | % | - |
| CHEMBL440975 | — | Activity | = | 83.0 | % | - |
| CHEMBL236080 | — | Activity | = | 75.0 | % | - |
| CHEMBL391367 | — | Activity | = | 81.0 | % | - |
| CHEMBL236290 | — | EC50 | - | — | - |