Assay Detail
Binding
CHEMBL896604
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Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay
25
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.00 | 9.70 |
| Activity | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39174 | — | — | 1 | 9.70 |
| CHEMBL236291 | — | — | 2 | 9.14 |
| CHEMBL41036 | — | — | 1 | 9.11 |
| CHEMBL236289 | — | — | 2 | 9.11 |
| CHEMBL391512 | — | — | 2 | 8.92 |
| CHEMBL391367 | — | — | 2 | 8.59 |
| CHEMBL440975 | — | — | 2 | 8.12 |
| CHEMBL236499 | — | — | 2 | 7.96 |
| CHEMBL236498 | — | — | 2 | 7.42 |
| CHEMBL236080 | — | — | 2 | 7.38 |
| CHEMBL393201 | — | — | 2 | 6.68 |
| CHEMBL236500 | — | — | 2 | 5.96 |
| CHEMBL391513 | — | — | 2 | 5.89 |
| CHEMBL236290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39174 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL236291 | — | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL41036 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL236289 | — | EC50 | = | 0.77 | nM | 9.11 |
| CHEMBL391512 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL391367 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL440975 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL236499 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL236498 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL236080 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL393201 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL236500 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL391513 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL440975 | — | Activity | = | 100.0 | % | - |
| CHEMBL236289 | — | Activity | = | 92.0 | % | - |
| CHEMBL236290 | — | EC50 | - | — | - | |
| CHEMBL391512 | — | Activity | = | 100.0 | % | - |
| CHEMBL391367 | — | Activity | = | 92.0 | % | - |
| CHEMBL236291 | — | Activity | = | 85.0 | % | - |
| CHEMBL391513 | — | Activity | = | 84.0 | % | - |
| CHEMBL236498 | — | Activity | = | 88.0 | % | - |
| CHEMBL236499 | — | Activity | = | 88.0 | % | - |
| CHEMBL393201 | — | Activity | = | 31.0 | % | - |
| CHEMBL236500 | — | Activity | = | 27.0 | % | - |
| CHEMBL236080 | — | Activity | = | 85.0 | % | - |