Assay Detail
Binding
CHEMBL896616
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Inhibition of human PNP in presence of 1 mM phosphate
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.54 | 8.02 |
| Ki | 3 | 8.11 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236711 | — | — | 2 | 8.28 |
| CHEMBL236709 | — | — | 2 | 8.09 |
| CHEMBL236708 | — | — | 2 | 7.97 |
| CHEMBL236710 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236711 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL236709 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL236711 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL236708 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL236708 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL236709 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL236710 | — | IC50 | = | 173.0 | nM | 6.76 |