Assay Detail
Binding
CHEMBL896683
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Inhibition of Leishmania tarentolae tubulin assembly
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania tarentolae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.12 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393580 | — | — | 1 | 5.18 |
| CHEMBL55225 | — | — | 1 | 5.13 |
| CHEMBL393396 | — | — | 1 | 5.04 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL236826 | — | — | 1 | - |
| CHEMBL237003 | — | — | 1 | - |
| CHEMBL237002 | — | — | 1 | - |
| CHEMBL237001 | — | — | 1 | - |
| CHEMBL236160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393580 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL55225 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL393396 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL265502 | SURAMIN | IC50 | - | — | - | |
| CHEMBL55 | PENTAMIDINE | IC50 | - | — | - | |
| CHEMBL236826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237003 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237002 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237001 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL236160 | — | IC50 | > | 100000.0 | nM | - |