Assay Detail
Functional
CHEMBL896686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition against Leishmania donovani
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.17 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55225 | — | — | 1 | 5.64 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.64 |
| CHEMBL393580 | — | — | 1 | 5.36 |
| CHEMBL393396 | — | — | 1 | 4.96 |
| CHEMBL236160 | — | — | 1 | 4.92 |
| CHEMBL236826 | — | — | 1 | 4.52 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
| CHEMBL237003 | — | — | 1 | - |
| CHEMBL237002 | — | — | 1 | - |
| CHEMBL237001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55225 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL393580 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL393396 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL236160 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL236826 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL265502 | SURAMIN | IC50 | - | — | - | |
| CHEMBL237003 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL237002 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL237001 | — | IC50 | > | 50000.0 | nM | - |