Assay Detail
Binding
CHEMBL896714
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Inhibition of CDK2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.82 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231950 | — | — | 1 | 7.52 |
| CHEMBL233553 | — | — | 1 | 6.92 |
| CHEMBL233149 | — | — | 1 | 6.75 |
| CHEMBL396614 | — | — | 1 | 6.24 |
| CHEMBL233554 | — | — | 1 | 6.24 |
| CHEMBL233970 | — | — | 1 | 6.21 |
| CHEMBL391493 | — | — | 1 | 5.54 |
| CHEMBL233765 | — | — | 1 | 5.03 |
| CHEMBL396360 | — | — | 1 | 4.72 |
| CHEMBL232148 | — | — | 1 | 4.57 |
| CHEMBL233349 | — | — | 1 | 4.33 |
| CHEMBL233763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231950 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL233553 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL233149 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL396614 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL233554 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL233970 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL391493 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL233765 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL396360 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL232148 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL233349 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL233763 | — | IC50 | = | 150000.0 | nM | - |