Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL896744

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and bioevaluation of N-(arylalkyl)-homospermidine conjugates.
Xie S, Cheng P, Liu G, Ma Y, Zhao J, Chehtane M, Khaled AR, Phanstiel O, Wang C.
Bioorg Med Chem Lett (2007) 17 : 4471 -4475
PubMed 17574415 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.35 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL540552 1 5.96
CHEMBL557367 1 5.92
CHEMBL540336 1 5.86
CHEMBL536075 1 5.72
CHEMBL536299 1 5.44
CHEMBL536076 1 5.44
CHEMBL536523 1 5.43
CHEMBL540379 1 5.02
CHEMBL237978 1 4.96
CHEMBL536524 1 4.95
CHEMBL233423 1 4.90
CHEMBL536525 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL540552 IC50 = 1100.0 nM 5.96
CHEMBL557367 IC50 = 1200.0 nM 5.92
CHEMBL540336 IC50 = 1380.0 nM 5.86
CHEMBL536075 IC50 = 1900.0 nM 5.72
CHEMBL536299 IC50 = 3600.0 nM 5.44
CHEMBL536076 IC50 = 3610.0 nM 5.44
CHEMBL536523 IC50 = 3700.0 nM 5.43
CHEMBL540379 IC50 = 9580.0 nM 5.02
CHEMBL237978 IC50 = 10870.0 nM 4.96
CHEMBL536524 IC50 = 11350.0 nM 4.95
CHEMBL233423 IC50 = 12540.0 nM 4.90
CHEMBL536525 IC50 = 26820.0 nM 4.57