Assay Detail
Functional
CHEMBL896757
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Cytotoxicity against high NQO1 protein expressing human H460 cells by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.47 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73822 | APAZIQUONE | 3.0 | 1 | 8.23 |
| CHEMBL609688 | — | — | 1 | 6.42 |
| CHEMBL609426 | — | — | 1 | 6.34 |
| CHEMBL609689 | — | — | 1 | 6.23 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.84 |
| CHEMBL609687 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73822 | APAZIQUONE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL609688 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL609426 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL609689 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL609687 | — | IC50 | = | 1880.0 | nM | 5.73 |