Assay Detail
Functional
CHEMBL896758
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Cytotoxicity against low NQO1 protein expressing human BE cells by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.05 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609688 | — | — | 1 | 6.24 |
| CHEMBL73822 | APAZIQUONE | 3.0 | 1 | 6.22 |
| CHEMBL609689 | — | — | 1 | 6.11 |
| CHEMBL609426 | — | — | 1 | 6.02 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.89 |
| CHEMBL609687 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609688 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL73822 | APAZIQUONE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL609689 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL609426 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL609687 | — | IC50 | = | 1480.0 | nM | 5.83 |