Assay Detail

CHEMBL896790

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Functional

Inhibition of cholesterol synthesis in rat liver

ChEMBL ↗

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Target

Liver (CHEMBL613642) ↗

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Primary target Liver

CHEMBL613642

Anchored from Assay target.

Protein identity Liver

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Liver
Confidence	1 — Organism
Curated By	Autocuration

Target

Liver (CHEMBL613642) ↗

Type	TISSUE
Organism	Rattus norvegicus

Publication

Aminopyrrolidineamide inhibitors of site-1 protease.

Hay BA, Abrams B, Zumbrunn AY, Valentine JJ, Warren LC, Petras SF, Shelly LD, Xia A, Varghese AH, Hawkins JL, Van Camp JA, Robbins MD, Landschulz K, Harwood HJ.
Bioorg Med Chem Lett (2007) 17 : 4411 -4414
PubMed 17583500 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.22	6.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL233611	—	—	1	6.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL233611	—	EC50	=	600.0	nM	6.22