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Assay Detail

CHEMBL896822

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Functional
Agonist activity at human LXRbeta receptor after 1 hr by HTRF cofactor recruitment assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.
Kher S, Lake K, Sircar I, Pannala M, Bakir F, Zapf J, Xu K, Zhang SH, Liu J, Morera L, Sakurai N, Jack R, Cheng JF.
Bioorg Med Chem Lett (2007) 17 : 4442 -4446
PubMed 17587573 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 6.48 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL392996 1 7.92
CHEMBL62136 T091317 1 7.82
CHEMBL59030 1 7.46
CHEMBL398381 1 7.24
CHEMBL393966 1 7.24
CHEMBL391853 1 6.92
CHEMBL397564 1 6.89
CHEMBL233369 1 6.72
CHEMBL397612 1 6.66
CHEMBL233571 1 6.66
CHEMBL233426 1 6.64
CHEMBL234802 1 6.52
CHEMBL231782 1 6.46
CHEMBL234591 1 6.44
CHEMBL234387 1 6.42
CHEMBL234388 1 6.38
CHEMBL233569 1 6.38
CHEMBL234594 1 6.31
CHEMBL391854 1 5.88
CHEMBL393967 1 5.82
CHEMBL391417 1 5.76
CHEMBL234806 1 5.75
CHEMBL233428 1 5.75
CHEMBL234595 1 5.75
CHEMBL234593 1 5.31
CHEMBL234592 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL392996 EC50 = 12.0 nM 7.92
CHEMBL62136 T091317 EC50 = 15.0 nM 7.82
CHEMBL59030 EC50 = 35.0 nM 7.46
CHEMBL398381 EC50 = 58.0 nM 7.24
CHEMBL393966 EC50 = 57.0 nM 7.24
CHEMBL391853 EC50 = 120.0 nM 6.92
CHEMBL397564 EC50 = 130.0 nM 6.89
CHEMBL233369 EC50 = 190.0 nM 6.72
CHEMBL397612 EC50 = 220.0 nM 6.66
CHEMBL233571 EC50 = 220.0 nM 6.66
CHEMBL233426 EC50 = 230.0 nM 6.64
CHEMBL234802 EC50 = 300.0 nM 6.52
CHEMBL231782 EC50 = 350.0 nM 6.46
CHEMBL234591 EC50 = 360.0 nM 6.44
CHEMBL234387 EC50 = 380.0 nM 6.42
CHEMBL234388 EC50 = 420.0 nM 6.38
CHEMBL233569 EC50 = 420.0 nM 6.38
CHEMBL234594 EC50 = 490.0 nM 6.31
CHEMBL391854 EC50 = 1320.0 nM 5.88
CHEMBL393967 EC50 = 1510.0 nM 5.82
CHEMBL391417 EC50 = 1750.0 nM 5.76
CHEMBL234806 EC50 = 1780.0 nM 5.75
CHEMBL233428 EC50 = 1800.0 nM 5.75
CHEMBL234595 EC50 = 1780.0 nM 5.75
CHEMBL234593 EC50 = 4900.0 nM 5.31
CHEMBL234592 EC50 = 5600.0 nM 5.25