Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL896881

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human U937 cells by MTS assay after 24 hrs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Autocuration

Target

U-937 (CHEMBL612794)
Type CELL-LINE
Organism Homo sapiens

Publication

An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.
Vine KL, Locke JM, Ranson M, Pyne SG, Bremner JB.
J Med Chem (2007) 50 : 5109 -5117
PubMed 17887662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.66 6.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL244322 1 6.31
CHEMBL244901 1 6.20
CHEMBL244712 1 6.12
CHEMBL396549 1 6.10
CHEMBL244899 1 6.05
CHEMBL244900 1 6.01
CHEMBL244711 1 5.95
CHEMBL244689 1 5.94
CHEMBL388274 1 5.92
CHEMBL244898 1 5.75
CHEMBL395485 1 5.74
CHEMBL395486 1 5.64
CHEMBL428921 1 5.64
CHEMBL396016 1 5.62
CHEMBL388910 1 5.62
CHEMBL244688 1 5.46
CHEMBL243451 1 5.28
CHEMBL396015 1 5.18
CHEMBL159 VINBLASTINE 4.0 1 5.16
CHEMBL244702 1 4.75
CHEMBL244509 1 4.47
CHEMBL389587 1 -
CHEMBL388026 1 -
CHEMBL387818 1 -
CHEMBL244534 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244322 IC50 = 490.0 nM 6.31
CHEMBL244901 IC50 = 630.0 nM 6.20
CHEMBL244712 IC50 = 760.0 nM 6.12
CHEMBL396549 IC50 = 800.0 nM 6.10
CHEMBL244899 IC50 = 890.0 nM 6.05
CHEMBL244900 IC50 = 980.0 nM 6.01
CHEMBL244711 IC50 = 1130.0 nM 5.95
CHEMBL244689 IC50 = 1140.0 nM 5.94
CHEMBL388274 IC50 = 1190.0 nM 5.92
CHEMBL244898 IC50 = 1760.0 nM 5.75
CHEMBL395485 IC50 = 1830.0 nM 5.74
CHEMBL395486 IC50 = 2270.0 nM 5.64
CHEMBL428921 IC50 = 2300.0 nM 5.64
CHEMBL396016 IC50 = 2400.0 nM 5.62
CHEMBL388910 IC50 = 2370.0 nM 5.62
CHEMBL244688 IC50 = 3440.0 nM 5.46
CHEMBL243451 IC50 = 5210.0 nM 5.28
CHEMBL396015 IC50 = 6670.0 nM 5.18
CHEMBL159 VINBLASTINE IC50 = 6880.0 nM 5.16
CHEMBL244702 IC50 = 17600.0 nM 4.75
CHEMBL244509 IC50 = 34100.0 nM 4.47
CHEMBL389587 IC50 > 36100.0 nM -
CHEMBL388026 IC50 > 36100.0 nM -
CHEMBL387818 IC50 > 46800.0 nM -
CHEMBL244534 IC50 > 14200.0 nM -