Assay Detail
Functional
CHEMBL896899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human LXRbeta receptor transfected in COS7 cells after 16 hrs by reporter transactivation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.92 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.96 |
| CHEMBL59030 | — | — | 1 | 7.82 |
| CHEMBL392996 | — | — | 1 | 7.38 |
| CHEMBL233369 | — | — | 1 | 7.19 |
| CHEMBL393966 | — | — | 1 | 6.54 |
| CHEMBL397564 | — | — | 1 | 6.24 |
| CHEMBL397612 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL59030 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL392996 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL233369 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL393966 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL397564 | — | EC50 | = | 576.0 | nM | 6.24 |
| CHEMBL397612 | — | EC50 | = | 4580.0 | nM | 5.34 |