Assay Detail
Binding
CHEMBL896996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.00 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396760 | — | — | 1 | 8.96 |
| CHEMBL439577 | — | — | 1 | 8.92 |
| CHEMBL245159 | — | — | 1 | 8.89 |
| CHEMBL396980 | — | — | 1 | 8.85 |
| CHEMBL244068 | — | — | 1 | 8.80 |
| CHEMBL245148 | — | — | 1 | 8.77 |
| CHEMBL438867 | — | — | 1 | 8.74 |
| CHEMBL245158 | — | — | 1 | 8.74 |
| CHEMBL245147 | — | — | 1 | 8.64 |
| CHEMBL245146 | — | — | 1 | 8.60 |
| CHEMBL245144 | — | — | 1 | 8.43 |
| CHEMBL245142 | — | — | 1 | 8.39 |
| CHEMBL191767 | — | — | 1 | 8.36 |
| CHEMBL245127 | — | — | 1 | 8.25 |
| CHEMBL245151 | — | — | 1 | 8.05 |
| CHEMBL244067 | — | — | 1 | 8.00 |
| CHEMBL245145 | — | — | 1 | 8.00 |
| CHEMBL396759 | — | — | 1 | 7.96 |
| CHEMBL396736 | — | — | 1 | 7.96 |
| CHEMBL245143 | — | — | 1 | 7.92 |
| CHEMBL242655 | — | — | 1 | 7.85 |
| CHEMBL245150 | — | — | 1 | 7.64 |
| CHEMBL388004 | — | — | 1 | 7.54 |
| CHEMBL245152 | — | — | 1 | 7.24 |
| CHEMBL245141 | — | — | 1 | 7.08 |
| CHEMBL244066 | — | — | 1 | 6.61 |
| CHEMBL398166 | — | — | 1 | 6.32 |
| CHEMBL397197 | — | — | 1 | 6.28 |
| CHEMBL242592 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396760 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL439577 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL245159 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL396980 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL244068 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL245148 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL438867 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL245158 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL245147 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL245146 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL245144 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL245142 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL191767 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL245127 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL245151 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL244067 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL245145 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL396759 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL396736 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL245143 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL242655 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL245150 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL388004 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL245152 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL245141 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL244066 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL398166 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL397197 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL242592 | — | IC50 | = | 746.0 | nM | 6.13 |