Assay Detail
Binding
CHEMBL897086
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Inhibition of TR by DTNB-coupled assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trypanothione reductase (CHEMBL1837) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei |
Publication
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.48 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537483 | — | — | 1 | 6.47 |
| CHEMBL233348 | — | — | 1 | 5.82 |
| CHEMBL233347 | — | — | 1 | 5.77 |
| CHEMBL538585 | — | — | 1 | 5.70 |
| CHEMBL233339 | — | — | 1 | 5.62 |
| CHEMBL535173 | — | — | 1 | 5.54 |
| CHEMBL536752 | — | — | 1 | 5.48 |
| CHEMBL233549 | — | — | 1 | 5.48 |
| CHEMBL392238 | — | — | 1 | 5.11 |
| CHEMBL55756 | — | — | 1 | 4.93 |
| CHEMBL395223 | — | — | 1 | 4.41 |
| CHEMBL231735 | — | — | 1 | - |
| CHEMBL234180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537483 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL233348 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL233347 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL538585 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL233339 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL535173 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL536752 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL233549 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL392238 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL55756 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL395223 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL231735 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL234180 | — | IC50 | = | 148000.0 | nM | - |