Assay Detail
Binding
CHEMBL897087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GR
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutathione reductase, mitochondrial (CHEMBL2755) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.37 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535173 | — | — | 1 | 4.69 |
| CHEMBL537483 | — | — | 1 | 4.69 |
| CHEMBL538585 | — | — | 1 | 4.60 |
| CHEMBL233347 | — | — | 1 | 4.24 |
| CHEMBL536752 | — | — | 1 | 4.19 |
| CHEMBL55756 | — | — | 1 | 4.10 |
| CHEMBL233348 | — | — | 1 | 4.06 |
| CHEMBL231735 | — | — | 1 | - |
| CHEMBL234180 | — | — | 1 | - |
| CHEMBL395223 | — | — | 1 | - |
| CHEMBL233549 | — | — | 1 | - |
| CHEMBL233339 | — | — | 1 | - |
| CHEMBL392238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535173 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL537483 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL538585 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL233347 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL536752 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL55756 | — | IC50 | = | 79300.0 | nM | 4.10 |
| CHEMBL233348 | — | IC50 | = | 86300.0 | nM | 4.06 |
| CHEMBL231735 | — | IC50 | > | 157000.0 | nM | - |
| CHEMBL234180 | — | IC50 | > | 212000.0 | nM | - |
| CHEMBL395223 | — | IC50 | > | 155000.0 | nM | - |
| CHEMBL233549 | — | IC50 | > | 173000.0 | nM | - |
| CHEMBL233339 | — | IC50 | > | 135000.0 | nM | - |
| CHEMBL392238 | — | IC50 | = | 105000.0 | nM | - |