Assay Detail
Binding
CHEMBL897349
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Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.29 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL234401 | — | — | 1 | 8.30 |
| CHEMBL234400 | — | — | 1 | 6.82 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.75 |
| CHEMBL393003 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL234401 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL234400 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL393003 | — | IC50 | = | 700.0 | nM | 6.16 |