Assay Detail
Functional
CHEMBL897532
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Antiproliferative activity against human PC3 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.32 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.55 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.00 |
| CHEMBL230741 | — | — | 1 | 7.60 |
| CHEMBL391405 | — | — | 1 | 7.12 |
| CHEMBL237263 | — | — | 1 | 6.99 |
| CHEMBL237475 | — | — | 1 | 6.93 |
| CHEMBL236835 | — | — | 1 | 6.70 |
| CHEMBL238333 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL61 | PODOFILOX | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL230741 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL391405 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL237263 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL237475 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL236835 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL238333 | — | IC50 | = | 203.0 | nM | 6.69 |