Assay Detail

CHEMBL897566

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [3H]clonidine from I1-imidazoline binding site in bovine adrenal medulla plasma membrane

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bos taurus
Tissue	Adrenal medulla
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis of 3,8,9-trisubstituted-1,7,9-triaza-fluorene-6-carboxylic acid derivatives as a new class of insulin secretagogues.

Bahekar RH, Jain MR, Jadav PA, Goel A, Patel DN, Prajapati VM, Gupta AA, Modi H, Patel PR.
Bioorg Med Chem (2007) 15 : 5950 -5964
PubMed 17583514 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	7.44	7.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL12014	HARMAN	—	1	7.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL12014	HARMAN	Ki	=	36.0	nM	7.44