Assay Detail
Functional
CHEMBL897633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
New chemical tools for investigating human mitotic kinesin Eg5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.35 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393844 | — | — | 1 | 5.42 |
| CHEMBL238076 | — | — | 1 | 5.41 |
| CHEMBL240689 | — | — | 1 | 5.41 |
| CHEMBL391848 | — | — | 1 | 5.30 |
| CHEMBL236789 | MONASTROL | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393844 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL238076 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL240689 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL391848 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL236789 | MONASTROL | IC50 | = | 6100.0 | nM | 5.21 |