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Assay Detail

CHEMBL897704

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Functional
Agonist activity at NK2 receptor in guinea pig smooth muscle
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Substance-K receptor (CHEMBL2647)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

alpha,alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists.
Sisto A, Altamura M, Cardinali F, D'Andrea P, Rossi C, Fattori D.
Bioorg Med Chem Lett (2007) 17 : 4841 -4844
PubMed 17604625 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.06 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL394419 1 7.70
CHEMBL394878 1 7.60
CHEMBL242631 1 7.60
CHEMBL398028 1 7.00
CHEMBL428203 1 7.00
CHEMBL237048 1 6.90
CHEMBL237097 1 6.70
CHEMBL394420 1 6.70
CHEMBL396827 1 6.70
CHEMBL394889 1 6.70
CHEMBL394648 1 -
CHEMBL237304 1 -
CHEMBL236661 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL394419 Ki = 19.95 nM 7.70
CHEMBL394878 Ki = 25.12 nM 7.60
CHEMBL242631 Ki = 25.12 nM 7.60
CHEMBL398028 Ki = 100.0 nM 7.00
CHEMBL428203 Ki = 100.0 nM 7.00
CHEMBL237048 Ki = 125.89 nM 6.90
CHEMBL237097 Ki = 199.53 nM 6.70
CHEMBL394420 Ki = 199.53 nM 6.70
CHEMBL396827 Ki = 199.53 nM 6.70
CHEMBL394889 Ki = 199.53 nM 6.70
CHEMBL394648 Ki < 3162.28 nM -
CHEMBL237304 Ki < 1000.0 nM -
CHEMBL236661 Ki < 1000.0 nM -