Assay Detail
Binding
CHEMBL897710
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Inhibition of human recombinant MMP14
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.48 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236400 | — | — | 1 | 6.00 |
| CHEMBL236573 | — | — | 1 | 5.62 |
| CHEMBL209970 | — | — | 1 | 5.44 |
| CHEMBL399401 | — | — | 1 | 5.44 |
| CHEMBL237468 | — | — | 1 | 5.37 |
| CHEMBL235559 | — | — | 1 | 5.31 |
| CHEMBL400430 | — | — | 1 | 5.15 |
| CHEMBL236572 | — | — | 1 | - |
| CHEMBL394003 | — | — | 1 | - |
| CHEMBL236806 | — | — | 1 | - |
| CHEMBL237467 | — | — | 1 | - |
| CHEMBL237466 | — | — | 1 | - |
| CHEMBL399400 | — | — | 1 | - |
| CHEMBL236574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236400 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL236573 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL209970 | — | IC50 | = | 3642.0 | nM | 5.44 |
| CHEMBL399401 | — | IC50 | = | 3619.0 | nM | 5.44 |
| CHEMBL237468 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL235559 | — | IC50 | = | 4891.0 | nM | 5.31 |
| CHEMBL400430 | — | IC50 | = | 7047.0 | nM | 5.15 |
| CHEMBL236572 | — | IC50 | - | — | - | |
| CHEMBL394003 | — | IC50 | - | — | - | |
| CHEMBL236806 | — | IC50 | - | — | - | |
| CHEMBL237467 | — | IC50 | - | — | - | |
| CHEMBL237466 | — | IC50 | - | — | - | |
| CHEMBL399400 | — | IC50 | - | — | - | |
| CHEMBL236574 | — | IC50 | - | — | - |