Assay Detail
Binding
CHEMBL898095
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MPEP from mGlu5 receptor in rat brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 5 (CHEMBL2564) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.68 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66654 | — | — | 1 | 8.24 |
| CHEMBL232188 | — | — | 1 | 7.66 |
| CHEMBL244796 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66654 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL232188 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL244796 | — | Ki | = | 72.0 | nM | 7.14 |