Assay Detail
Binding
CHEMBL898174
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Inhibition of human DAT expressed in COS1 cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 4.85 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396386 | — | — | 1 | 5.96 |
| CHEMBL235409 | — | — | 1 | 5.76 |
| CHEMBL245061 | — | — | 1 | 5.71 |
| CHEMBL396082 | — | — | 1 | 5.38 |
| CHEMBL391912 | — | — | 1 | 5.37 |
| CHEMBL235626 | — | — | 1 | 5.17 |
| CHEMBL232068 | — | — | 1 | 4.93 |
| CHEMBL235833 | — | — | 1 | 4.83 |
| CHEMBL235408 | — | — | 1 | 4.74 |
| CHEMBL392927 | — | — | 1 | 4.64 |
| CHEMBL391911 | — | — | 1 | 4.61 |
| CHEMBL396839 | — | — | 1 | 4.60 |
| CHEMBL235189 | — | — | 1 | 4.57 |
| CHEMBL235351 | — | — | 1 | 4.49 |
| CHEMBL236422 | — | — | 1 | 4.47 |
| CHEMBL232671 | — | — | 1 | 4.46 |
| CHEMBL429630 | — | — | 1 | 4.25 |
| CHEMBL438682 | — | — | 1 | 4.17 |
| CHEMBL232870 | — | — | 1 | 4.07 |
| CHEMBL231858 | — | — | 1 | - |
| CHEMBL396840 | — | — | 1 | - |
| CHEMBL235625 | — | — | 1 | - |
| CHEMBL236473 | — | — | 1 | - |
| CHEMBL394470 | — | — | 1 | - |
| CHEMBL234127 | — | — | 1 | - |
| CHEMBL232672 | — | — | 1 | - |
| CHEMBL396083 | — | — | 1 | - |
| CHEMBL232866 | — | — | 1 | - |
| CHEMBL232674 | — | — | 1 | - |
| CHEMBL232867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396386 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL235409 | — | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL245061 | — | Ki | = | 1949.84 | nM | 5.71 |
| CHEMBL396082 | — | Ki | = | 4168.69 | nM | 5.38 |
| CHEMBL391912 | — | Ki | = | 4265.8 | nM | 5.37 |
| CHEMBL235626 | — | Ki | = | 6760.83 | nM | 5.17 |
| CHEMBL232068 | — | Ki | = | 11748.98 | nM | 4.93 |
| CHEMBL235833 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL235408 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL392927 | — | Ki | = | 22908.68 | nM | 4.64 |
| CHEMBL391911 | — | Ki | = | 24547.09 | nM | 4.61 |
| CHEMBL396839 | — | Ki | = | 25118.86 | nM | 4.60 |
| CHEMBL235189 | — | Ki | = | 26915.35 | nM | 4.57 |
| CHEMBL235351 | — | Ki | = | 32200.0 | nM | 4.49 |
| CHEMBL236422 | — | Ki | = | 33884.42 | nM | 4.47 |
| CHEMBL232671 | — | Ki | = | 34673.69 | nM | 4.46 |
| CHEMBL429630 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL438682 | — | Ki | = | 67900.0 | nM | 4.17 |
| CHEMBL232870 | — | Ki | = | 85113.8 | nM | 4.07 |
| CHEMBL231858 | — | Ki | = | 117489.76 | nM | - |
| CHEMBL396840 | — | Ki | = | 371535.23 | nM | - |
| CHEMBL235625 | — | Ki | = | 602559.59 | nM | - |
| CHEMBL236473 | — | Ki | = | 232000.0 | nM | - |
| CHEMBL394470 | — | Ki | = | 446683.59 | nM | - |
| CHEMBL234127 | — | Ki | = | 630957.34 | nM | - |
| CHEMBL232672 | — | Ki | = | 141253.75 | nM | - |
| CHEMBL396083 | — | Ki | = | 301995.17 | nM | - |
| CHEMBL232866 | — | Ki | = | 2630267.99 | nM | - |
| CHEMBL232674 | — | Ki | = | 870963.59 | nM | - |
| CHEMBL232867 | — | Ki | = | 331131.12 | nM | - |
| CHEMBL393386 | — | Ki | = | 104712.85 | nM | - |
| CHEMBL232069 | — | Ki | = | 263026.8 | nM | - |
| CHEMBL396838 | — | Ki | = | 645654.23 | nM | - |