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Assay Detail

CHEMBL898303

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Low molecular weight phosphotyrosine protein phosphatase (CHEMBL5397)
Type SINGLE PROTEIN
Organism Saccharomyces cerevisiae S288c

Publication

5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.
Maccari R, Paoli P, Ottanà R, Jacomelli M, Ciurleo R, Manao G, Steindl T, Langer T, Vigorita MG, Camici G.
Bioorg Med Chem (2007) 15 : 5137 -5149
PubMed 17543532 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.50 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL235595 1 4.82
CHEMBL235596 1 4.71
CHEMBL393606 1 4.47
CHEMBL392379 1 4.00
CHEMBL392380 1 -
CHEMBL236024 1 -
CHEMBL397791 1 -
CHEMBL235805 1 -
CHEMBL235804 1 -
CHEMBL235372 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL235595 IC50 = 15000.0 nM 4.82
CHEMBL235596 IC50 = 19700.0 nM 4.71
CHEMBL393606 IC50 = 34000.0 nM 4.47
CHEMBL392379 IC50 = 99000.0 nM 4.00
CHEMBL392380 IC50 > 450000.0 nM -
CHEMBL236024 IC50 = 1395000.0 nM -
CHEMBL397791 IC50 = 188000.0 nM -
CHEMBL235805 IC50 = 389000.0 nM -
CHEMBL235804 IC50 = 149000.0 nM -
CHEMBL235372 IC50 = 483000.0 nM -