Assay Detail
Functional
CHEMBL898381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.32 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.19 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.92 |
| CHEMBL392729 | — | — | 1 | 6.75 |
| CHEMBL392519 | — | — | 1 | 6.70 |
| CHEMBL392520 | — | — | 1 | 6.60 |
| CHEMBL235111 | — | — | 1 | 6.47 |
| CHEMBL237613 | — | — | 1 | 6.43 |
| CHEMBL392919 | — | — | 1 | 6.41 |
| CHEMBL235527 | — | — | 1 | 6.38 |
| CHEMBL235322 | — | — | 1 | 6.35 |
| CHEMBL237458 | — | — | 1 | 6.33 |
| CHEMBL237612 | — | — | 1 | 6.28 |
| CHEMBL235112 | — | — | 1 | 6.26 |
| CHEMBL443314 | — | — | 1 | 6.20 |
| CHEMBL235321 | — | — | 1 | 6.16 |
| CHEMBL394001 | — | — | 1 | 6.16 |
| CHEMBL235333 | — | — | 1 | 6.15 |
| CHEMBL375980 | — | — | 1 | 6.08 |
| CHEMBL398994 | — | — | 1 | 6.00 |
| CHEMBL219419 | — | — | 1 | 5.62 |
| CHEMBL235539 | — | — | 1 | 5.57 |
| CHEMBL235528 | — | — | 1 | 5.10 |
| CHEMBL374245 | — | — | 1 | - |
| CHEMBL392918 | — | — | 1 | - |
| CHEMBL400221 | — | — | 1 | - |
| CHEMBL400220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL392729 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL392519 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL392520 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL235111 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL237613 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL392919 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL235527 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL235322 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL237458 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL237612 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL235112 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL443314 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL235321 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL394001 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL235333 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL375980 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL398994 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL219419 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL235539 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL235528 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL374245 | — | IC50 | > | 15550.0 | nM | - |
| CHEMBL392918 | — | IC50 | > | 10990.0 | nM | - |
| CHEMBL400221 | — | IC50 | > | 11740.0 | nM | - |
| CHEMBL400220 | — | IC50 | > | 12500.0 | nM | - |