Assay Detail
Functional
CHEMBL898386
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Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Plasmodium falciparum VS1 after 24 hrs
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-malarial activity of N6-modified purine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.98 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397824 | — | — | 1 | 6.54 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.07 |
| CHEMBL393474 | — | — | 1 | 5.25 |
| CHEMBL236757 | — | — | 1 | 5.10 |
| CHEMBL236537 | — | — | 1 | 5.07 |
| CHEMBL236766 | — | — | 1 | 5.01 |
| CHEMBL398404 | — | — | 1 | 4.96 |
| CHEMBL397156 | — | — | 1 | 4.91 |
| CHEMBL236538 | — | — | 1 | 4.88 |
| CHEMBL392756 | — | — | 1 | 4.85 |
| CHEMBL395170 | — | — | 1 | 4.78 |
| CHEMBL394752 | — | — | 1 | 4.73 |
| CHEMBL394272 | — | — | 1 | 4.70 |
| CHEMBL395634 | — | — | 1 | 4.65 |
| CHEMBL235303 | — | — | 1 | 4.60 |
| CHEMBL237237 | — | — | 1 | 4.47 |
| CHEMBL237170 | — | — | 1 | 4.05 |
| CHEMBL395401 | — | — | 1 | - |
| CHEMBL237173 | — | — | 1 | - |
| CHEMBL236767 | — | — | 1 | - |
| CHEMBL235087 | — | — | 1 | - |
| CHEMBL394981 | — | — | 1 | - |
| CHEMBL392973 | — | — | 1 | - |
| CHEMBL235089 | — | — | 1 | - |
| CHEMBL237009 | — | — | 1 | - |
| CHEMBL237011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397824 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL393474 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL236757 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL236537 | — | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL236766 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL398404 | — | IC50 | = | 10960.0 | nM | 4.96 |
| CHEMBL397156 | — | IC50 | = | 12220.0 | nM | 4.91 |
| CHEMBL236538 | — | IC50 | = | 13330.0 | nM | 4.88 |
| CHEMBL392756 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL395170 | — | IC50 | = | 16790.0 | nM | 4.78 |
| CHEMBL394752 | — | IC50 | = | 18770.0 | nM | 4.73 |
| CHEMBL394272 | — | IC50 | = | 19820.0 | nM | 4.70 |
| CHEMBL395634 | — | IC50 | = | 22470.0 | nM | 4.65 |
| CHEMBL235303 | — | IC50 | = | 25220.0 | nM | 4.60 |
| CHEMBL237237 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL237170 | — | IC50 | = | 89320.0 | nM | 4.05 |
| CHEMBL395401 | — | IC50 | > | 555000.0 | nM | - |
| CHEMBL237173 | — | IC50 | > | 606000.0 | nM | - |
| CHEMBL236767 | — | IC50 | = | 224780.0 | nM | - |
| CHEMBL235087 | — | IC50 | = | 418510.0 | nM | - |
| CHEMBL394981 | — | IC50 | > | 558000.0 | nM | - |
| CHEMBL392973 | — | IC50 | > | 306000.0 | nM | - |
| CHEMBL235089 | — | IC50 | > | 613000.0 | nM | - |
| CHEMBL237009 | — | IC50 | = | 126060.0 | nM | - |
| CHEMBL237011 | — | IC50 | = | 351630.0 | nM | - |