Assay Detail
Functional
CHEMBL898401
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Antiproliferative activity against human SW480 cells after 72 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.92 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.46 |
| CHEMBL236764 | — | — | 1 | 5.33 |
| CHEMBL235934 | CLAUSINE E | — | 1 | 5.32 |
| CHEMBL236763 | — | — | 1 | 5.06 |
| CHEMBL393476 | — | — | 1 | 4.20 |
| CHEMBL236143 | MUKONINE | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL236764 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL235934 | CLAUSINE E | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL236763 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL393476 | — | IC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL236143 | MUKONINE | IC50 | = | 72000.0 | nM | 4.14 |