Assay Detail
Functional
CHEMBL898406
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Mitotic arrest in Pgp overexpressing KBV1 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-V1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.06 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL400042 | — | — | 1 | 8.47 |
| CHEMBL240923 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL400042 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL240923 | — | EC50 | = | 22.5 | nM | 7.65 |