Assay Detail
Functional
CHEMBL898454
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Inhibition of cholesterol synthesis in rat liver hepatocytes after 4 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 9.14 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398403 | — | — | 1 | 9.96 |
| CHEMBL235472 | — | — | 1 | 9.82 |
| CHEMBL262322 | — | — | 1 | 9.77 |
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 9.64 |
| CHEMBL237596 | — | — | 1 | 9.62 |
| CHEMBL237814 | — | — | 1 | 9.55 |
| CHEMBL427854 | — | — | 1 | 9.54 |
| CHEMBL392897 | — | — | 1 | 9.46 |
| CHEMBL394937 | — | — | 1 | 9.37 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 8.89 |
| CHEMBL1477 | CERIVASTATIN | 4.0 | 1 | 8.77 |
| CHEMBL235712 | — | — | 1 | 8.68 |
| CHEMBL235709 | — | — | 1 | 8.31 |
| CHEMBL391241 | — | — | 1 | 8.29 |
| CHEMBL237597 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398403 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL235472 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL262322 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL237596 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL237814 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL427854 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL392897 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL394937 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1477 | CERIVASTATIN | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL235712 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL235709 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL391241 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL237597 | — | IC50 | = | 32.0 | nM | 7.50 |