Assay Detail
Binding
CHEMBL898630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Chk1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of isogranulatimide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.84 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239698 | — | — | 1 | 7.80 |
| CHEMBL393545 | — | — | 1 | 7.62 |
| CHEMBL238625 | — | — | 1 | 7.18 |
| CHEMBL240747 | GRANULATIMIDE | — | 1 | 7.10 |
| CHEMBL392052 | — | — | 1 | 7.05 |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | 6.36 |
| CHEMBL427684 | — | — | 1 | 6.19 |
| CHEMBL392154 | — | — | 1 | 5.44 |
| CHEMBL239697 | — | — | 1 | - |
| CHEMBL400012 | — | — | 1 | - |
| CHEMBL392153 | — | — | 1 | - |
| CHEMBL392940 | — | — | 1 | - |
| CHEMBL392737 | — | — | 1 | - |
| CHEMBL400203 | — | — | 1 | - |
| CHEMBL391232 | — | — | 1 | - |
| CHEMBL392053 | — | — | 1 | - |
| CHEMBL392700 | — | — | 1 | - |
| CHEMBL239914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239698 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL393545 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL238625 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL240747 | GRANULATIMIDE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL392052 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL427684 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL392154 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL239697 | — | IC50 | - | — | - | |
| CHEMBL400012 | — | IC50 | - | — | - | |
| CHEMBL392153 | — | IC50 | - | — | - | |
| CHEMBL392940 | — | IC50 | - | — | - | |
| CHEMBL392737 | — | IC50 | - | — | - | |
| CHEMBL400203 | — | IC50 | - | — | - | |
| CHEMBL391232 | — | IC50 | - | — | - | |
| CHEMBL392053 | — | IC50 | - | — | - | |
| CHEMBL392700 | — | IC50 | - | — | - | |
| CHEMBL239914 | — | IC50 | - | — | - |