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Assay Detail

CHEMBL898632

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against mouse L1210 cells after 4 hrs by microculture tetrazolium assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Autocuration

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological activities of isogranulatimide analogues.
Hugon B, Anizon F, Bailly C, Golsteyn RM, Pierré A, Léonce S, Hickman J, Pfeiffer B, Prudhomme M.
Bioorg Med Chem (2007) 15 : 5965 -5980
PubMed 17582773 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.86 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL240747 GRANULATIMIDE 1 5.55
CHEMBL393545 1 5.51
CHEMBL239698 1 5.35
CHEMBL392700 1 5.31
CHEMBL239914 1 5.27
CHEMBL392737 1 5.06
CHEMBL413188 ISOGRANULATIMIDE 1 5.00
CHEMBL238625 1 4.90
CHEMBL392052 1 4.83
CHEMBL427684 1 4.57
CHEMBL392154 1 4.54
CHEMBL400012 1 4.48
CHEMBL392053 1 4.38
CHEMBL400203 1 4.37
CHEMBL391232 1 4.36
CHEMBL239697 1 4.31
CHEMBL392940 1 -
CHEMBL392153 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL240747 GRANULATIMIDE IC50 = 2800.0 nM 5.55
CHEMBL393545 IC50 = 3100.0 nM 5.51
CHEMBL239698 IC50 = 4500.0 nM 5.35
CHEMBL392700 IC50 = 4900.0 nM 5.31
CHEMBL239914 IC50 = 5400.0 nM 5.27
CHEMBL392737 IC50 = 8800.0 nM 5.06
CHEMBL413188 ISOGRANULATIMIDE IC50 = 10000.0 nM 5.00
CHEMBL238625 IC50 = 12500.0 nM 4.90
CHEMBL392052 IC50 = 14700.0 nM 4.83
CHEMBL427684 IC50 = 27000.0 nM 4.57
CHEMBL392154 IC50 = 29200.0 nM 4.54
CHEMBL400012 IC50 = 33000.0 nM 4.48
CHEMBL392053 IC50 = 41200.0 nM 4.38
CHEMBL400203 IC50 = 42700.0 nM 4.37
CHEMBL391232 IC50 = 43500.0 nM 4.36
CHEMBL239697 IC50 = 48700.0 nM 4.31
CHEMBL392940 IC50 > 100000.0 nM -
CHEMBL392153 IC50 > 100000.0 nM -