Assay Detail
Binding
CHEMBL898700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I](E)-3-(4-(Dimethylamino-phenyl)-1-(4-iodophenyl)prop-2-en-1-one from beta amyloid(1-42) aggregates
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.92 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240573 | — | — | 1 | 8.54 |
| CHEMBL239693 | — | — | 1 | 8.20 |
| CHEMBL394456 | — | — | 1 | 8.20 |
| CHEMBL239037 | — | — | 1 | 7.67 |
| CHEMBL241164 | — | — | 1 | 6.98 |
| CHEMBL429694 | CONGO RED | -1.0 | 1 | - |
| CHEMBL224392 | THIOFLAVIN T | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240573 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL239693 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL394456 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL239037 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL241164 | — | Ki | = | 104.7 | nM | 6.98 |
| CHEMBL429694 | CONGO RED | Ki | > | 10000.0 | nM | - |
| CHEMBL224392 | THIOFLAVIN T | Ki | > | 10000.0 | nM | - |